Temperature-
Responsive
Hydrogel (TRH) Technology
is a drug delivery system that remains liquid (Sol) at room temperature but turns into a gel at body temperature. When mixed with drugs, it can be directly injected into the target site, enabling the sustained release of therapeutic drugs for 72 hours.
Technology Overview
Key Characteristics of Temperature-Responsive Hydrogel (TRH) Technology
- Here are the core properties of Temperature-Responsive Hydrogels (TRH):
- ①Sustained Drug Delivery Platform: TRH serves as a platform technology for the sustained release of therapeutic agents.
- ②Minimal Side Effects: It undergoes only physical phase changes without chemical reactions, ensuring no toxicity or systemic side effects in the body.
- ③Versatile Application: TRH can be mixed with local anesthetics (like Ropivacaine) for use across various indications.
Sustained drug release for 72 hours Temperature-Responsive Hydrogel (TRH) Functionality
TRH is designed for ease of use and prolonged effect. It can be injected or applied to the affected area as a liquid at room temperature. Upon contact with body temperature, it transitions into a gel state, continuously releasing medication for 72 hours.
Safe Drug Delivery Device TRH-Based System
This innovative drug delivery device leverages the unique properties of TRH (Temperature-Responsive Hydrogel) to provide a safe and effective method for sustained drug release. It transforms from a liquid to a gel through purely physical interactions, without any chemical cross-linking. As a result, it shows no inherent toxicity and minimizes the risk of in-vivo side effects.
Key Ingredients of Temperature-Responsive Hydrogel (TRH)
-
Poloxamer - A temperature-responsive polymer
Aqueous solutions of Poloxamers exhibit a remarkable and highly useful characteristic: thermo-reversibility. This means their physical state (liquid or gel) changes predictably with temperature, and this change can be reversed by adjusting the temperature back. -
Sodium Hyaluronate (SH)
allows the active ingredient of the liquid injectable drug to be slowly released into the body.
